【摘 要】
：
To understand metastasis of squamous cell carcinoma of the head and neck (SCCHN), we previously established a lymph node metastatic SCCHN xenograft mouse model and selected highly metastatic SCCHN cel
【机 构】
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Hematology and Medical Oncology Georgia Cancer Coalition Distinguished Cancer Scholar USA
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
To understand metastasis of squamous cell carcinoma of the head and neck (SCCHN), we previously established a lymph node metastatic SCCHN xenograft mouse model and selected highly metastatic SCCHN cell lines from a poorly metastatic parental cell line through this model.The selected metastatic cells induced high incidences of lymph node and lung metastases, whereas rare lymph node and no lung metastases were observed with the parental SCCHN cells.Further analysis of these metastatic cells by DNA microarray and other biological assays highlighted some features of cancer stem cells (CSC) in this highly metastatic subpopulation.Our data showed that these metastatic cells expressed low levels of epithelial cell differentiation markers E-cadherin and involucrin.However, we observed enhanced levels of the mesenchymal cell marker, vimentin and epithelial stem cell markers, intergrin 1 and CXCR4, compared with their parental cells.
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