【摘 要】
：
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor family involved in the expression of genes involved in several biologic cellular processes.There are thre
【机 构】
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University of Colorado Denver Denver Heath Medical Center USA
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor family involved in the expression of genes involved in several biologic cellular processes.There are three different isotypes of PPAR: PPAR-α, PPAR-δ and PPAR-γ.They are encoded by different genes and they seem to have different tissue distribution and function.PPAR isoforms bind as heterodimers with the retinoic acid X receptor to specific regulatory promoter elements unchaining different effects in gene transcription.PPAR have been implicated in lipid metabolism and insulin sensitivity, however, most recently and in special PPAR-γ has been involved in regulation of inflammatory and cellular reparative responses.PPAR-γ has been also identified to play an important role in adipocyte differentiation.
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