【摘 要】
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OBJECTIVE To investigated whether acute subcu taneous administration of G.elegans alkaloids (eg, gelsemine,koumine, gelsevirine, gelsenicine) were capable of exerting anx iolytic and antidepressant ef
【机 构】
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Department of Pharmacology, College of Pharmacy, Fujian Medical University, Fuzhou 350004, China
【出 处】
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第十五届中国神经精神药理学学术会议
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OBJECTIVE To investigated whether acute subcu taneous administration of G.elegans alkaloids (eg, gelsemine,koumine, gelsevirine, gelsenicine) were capable of exerting anx iolytic and antidepressant effects in mouse models of these disor ders.METHODS We used two mouse models of anxiety (ele vated plus-maze and light-dark transition model), and two mouse models of depression (forced swim test and tail suspension test)to examine whether the G.elegans alkaloids are capable of atten uating anxiety-and depressive-like behaviors.RESULTS Gelsemine, koumine and gelsevirine exhibited potent anxiolytic effects in both the elevated plus-maze and the light-dark transi tion model.Gelsenicine, on the other hand, had no effect on the behavioural response in either of the anxiety models.None of the G.elegans alkaloids exerted antidepressant effects in the forced swim test and the tail suspension test.Importantly, none of the G.elegans alkaloids impaired spontaneous motor activities.CONCLUSION Gelsemine, koumine and gelsevirine might serve as potential candidates for the treatment of anxiety-related disorders in clinical trials with human patients.
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