我们曾报道人工合成的糖皮质激素地塞米松(Dex)能通过上调小G蛋白RhoB的表达抑制多种肿瘤细胞的增殖。本研究发现Dex能够导致卵巢癌细胞变形、细胞骨架重构和应力纤维形成,并明显抑制细胞的迁移和侵袭。我们进一步观察了 We have reported that the synthetic glucocorticoid dexamethasone (Dex) can inhibit the proliferation of a variety of tumor cells by up-regulating the expression of the small G protein RhoB. This study found that Dex can lead to ovarian cancer cell deformation, cytoskeletal remodeling and stress fiber formation, and significantly inhibit cell migration and invasion. Let’s take a closer look