Total Synthesis of D Form African Swine Fever Virus Polymerase X

来源 :第十三届中国国际多肽大会 | 被引量 : 0次 | 上传用户：llaaxzl123

【摘要】

：

　　DNA polymerase is a critical protein utilized in Polymerase Chain Reaction(PCR)which is a fundamental biochemical technology in molecular biology.The produc

【作者】

：

Weiliang Xu Zimou Wang Ting Zhu Lei Liu

【机构】

：

DepartmentofChemistry,TsinghuaUniversity,Beijing,ChinaSchoolofLifeSciences,TsinghuaUniversity,Beijin

【出处】

：

第十三届中国国际多肽大会

【发表日期】

：

2014年6期

【关键词】

：

protein total synthesis DNA polymerase mirror image

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　　DNA polymerase is a critical protein utilized in Polymerase Chain Reaction(PCR)which is a fundamental biochemical technology in molecular biology.The production of nucleic acid aptamer based on Systematic Evolution of Ligands by Exponential Enrichment(SELEX)is one of the attractive fields of PCR application [1].In order to increase the stability of aptamer in vivo,mirror image of natural D-aptamer is an ideal candidate.Therefore,D-polymerase which is the mirror image of its natural counterpart is needed in SELEX.However,D-protein must be obtained through total chemical synthesis under the assistance of Solid Phase Peptide Synthesis(SPPS)and Native Chemical Ligation(NCL).

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Total Synthesis of D Form African Swine Fever Virus Polymerase X

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