【摘 要】
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Polysubstituted imidazo [1,2-α]pyridines(IPY) are well established as privileged scaffolds which are commonly encountered in many biological active natural pro
【机 构】
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SchoolofChemistryandChemicalEngineering,SouthChinaUniversityofTechnology,Guangzhou,510640
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
Polysubstituted imidazo [1,2-α]pyridines(IPY) are well established as privileged scaffolds which are commonly encountered in many biological active natural products and medicinal molecules.In the past decades,much significant progress about transition metal-catalyzed synthesis of IPY derivatives has been achieved.Among them,palladium,copper,gold,and silver catalysts et al have been widely employed to develop various synthetic strategies for rapidly assembling these compounds.However,most of transition-metal salts are environmental-unfriendly to different extents,and removal of trace amounts of residual metal from pharmaceutical precursors such as IPY generally still suffers from high cost and complicate purifying procedure.Therefore developing metal-free synthetic reactions will provide a direct and powerful tool to meet these challenges.
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