Myocardial Expression, Signaling, and Function of Chemokine Receptor4 (CXCR4): Effects of CXCR4 Gene

来源 :BITs 2rd Annual World Cancer Congress of Cardiology-2010(201 | 被引量 : 0次 | 上传用户:tcf274617008
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  Acute coronary occlusion is the leading cause of death in the Westem World.There is an unmet need for the development of treatments to limit the extent of myocardial infarction (MI) during the acute phase of occlusion.Recently, investigators have focused on the use ofa chemokine, CXCL12, the only identified ligand for CXCR4, as a new therapeutic modality to recruit stem cells to individuals suffering from MI.Here, we examined the effects of over-expression of CXCR4 by gene transfer on MI.
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