KSHV INDUCES NRF2 DURING DE NOVO INFECTION OF ENDOTHELIAL CELLS TO CREATE A MICROENVIRONMENT CONDUCI

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：abcoabco1

【摘要】

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Our studies have shown that KSHV induces oxidative stress (ROS) early during infection of human dermal microvascular endothelial (HMVEC-d) cells that is critica

【作者】

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Olsi Giyshi Virginie Bottero Mohanan Valiya Veettil Sujoy Dutta Vivek Vikram singh Leela Chikoti Bala Chandran

【机构】

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H.M.BlighCancerResearchLaboratories,DepartmentofMicrobiologyandImmunology,ChicagoMedicalSchool,Rosal

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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Our studies have shown that KSHV induces oxidative stress (ROS) early during infection of human dermal microvascular endothelial (HMVEC-d) cells that is critical for virus entry (J Virol, 2013.87.1733-49).One of the downstream targets of ROS is Nrf2 (Nuclear Factor E2-Related Factor 2), a member of the bZip family of transcription factors, which plays a crucial role in antioxidative response.

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KSHV INDUCES NRF2 DURING DE NOVO INFECTION OF ENDOTHELIAL CELLS TO CREATE A MICROENVIRONMENT CONDUCI

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