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  5. CHD1L knockdown significantly inhibits human embryonic stem cell self-renewal

CHD1L knockdown significantly inhibits human embryonic stem cell self-renewal

来源 :The 7th Guangzhou International Conference on Stem Cell and | 被引量 : 0次 | 上传用户：qf0909
【摘 要】
：
Overexpression of CHD1L (chromodomain helicase/ATPase DNA binding protein 1 like gene) is highly associated with poor prognosis in many malignancies.However,the function of CHD1L in human Embryonic St
【作 者】
：
Dandan Dou Xingwu Wu Liang Hu 
【机 构】
：
Institute of Reproductive and Stem Cell Engineering,Central South University,Changsha 410001,China;N
【出 处】
：
The 7th Guangzhou International Conference on Stem Cell and
【发表日期】
：
2014年5期
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Overexpression of CHD1L (chromodomain helicase/ATPase DNA binding protein 1 like gene) is highly associated with poor prognosis in many malignancies.However,the function of CHD1L in human Embryonic Sten Cell (hESC) remains unknown.Here,we showed that CHD1L knockdown significantly inhibited self-renewal of hESCs.The protein level of CHD1L was significantly higher in the pluripotent cells than those in differentiated cells and CHD1L was downregulated during hESC spontaneous differentiation.
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