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DNA 甲基化在真核生物中广泛存在,与细胞分化、胚胎发育、环境适应和疾病发生等各种功能相关,是重要的表观遗传学标记,也是当前表观遗传学研究的热点领域之一.研究表明,DNA 甲基化可以通过调控转录因子和DNA 的结合特异性来发挥作用,但是目前其分子机制尚不清楚.
单位点DNA甲基化对C/EBPβ转录因子与DNA特异性识别序列相互影响机制的分子动力模拟研究
【摘 要】
：
DNA 甲基化在真核生物中广泛存在,与细胞分化、胚胎发育、环境适应和疾病发生等各种功能相关,是重要的表观遗传学标记,也是当前表观遗传学研究的热点领域之一.研究表明,DNA 甲基化可以通过调控转录因子和DNA 的结合特异性来发挥作用,但是目前其分子机制尚不清楚.
【出 处】
：
中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛
【发表日期】
：
2017年10期
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