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Inactivation is an important gating property that distinguishes Kv4 from other rapidly inactivating Kv channels, since its midpoint of steady-state inactivation is typically below the channel activation threshold and close to the resting membrane potential in neurons.This preferential closed-state inactivation (CSI), functionally coupled with subthreshold excitatory postsynaptic potentials (EPSPs), causes the inhibition of Kv4 channel activity without requirement for channel opening.