Suppression of Kv4 Closed-state Inactivation by the Distinct T1-T1 Interface consisting of the C3H1

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：hmgujie

【摘要】

：

【作者】

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Yi-Quan Tang Fan Yang Jingheng Zhou Jie Zheng KeWei Wang

【机构】

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Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Dr

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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closed-state inactivation Kv4T1 domain C3H1 motif

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Inactivation is an important gating property that distinguishes Kv4 from other rapidly inactivating Kv channels, since its midpoint of steady-state inactivation is typically below the channel activation threshold and close to the resting membrane potential in neurons.This preferential closed-state inactivation (CSI), functionally coupled with subthreshold excitatory postsynaptic potentials (EPSPs), causes the inhibition of Kv4 channel activity without requirement for channel opening.

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Suppression of Kv4 Closed-state Inactivation by the Distinct T1-T1 Interface consisting of the C3H1

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