Dynamic Ca2+ sensitivity of BK channels

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：wqh4975156

【摘要】

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【作者】

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Panpan Hou Jianming Cui Ding Jiuping Feng Xiao Ming Yuchi Guohui Zhang Ying Wu Wei Wang Wenping Zeng Mingyue Ding Zhengxing Wu

【机构】

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Key Laboratory of Molecular Biophysics, Huazhong University of Science and Technology, Ministry of E

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

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Large-conductance calcium-activated K+ (BK-type, mSlol or mutations) channels, abundantly distributed in the excitable cells, response to the Ca2+-influx to regulate membrane potentials.However, it remains unknown how they react to the fast Ca2+-influx.Flash photolysis provides the most rapidly calcium release for detecting actions of Ca2+-binding proteins.In this study, our results revealed that the uncaged Ca2+ activated a voltage-and calcium-independent biphasic BK current with τf～0.2 ms and τs～10 ms, of which the fast component ratio Rf is voltage-dependent only.We further demonstrated that this occurred as the uncaged Ca2+ was not a constant.

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Dynamic Ca2+ sensitivity of BK channels

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