【摘 要】
：
Force has been increasingly recognized as an important element for the control of a large variety of biological processes.Force can change the conformation of a
【机 构】
：
南京大学物理学院,210093,江苏南京
【出 处】
：
中国化学会第三届全国生物物理化学会议暨国际华人生物物理化学发展论坛
论文部分内容阅读
Force has been increasingly recognized as an important element for the control of a large variety of biological processes.Force can change the conformation of a protein or even trigger the unfolding,leading to many force specific effects.With the development of single molecule force spectroscopy techniques,the mechanical properties of single protein molecules have been studied in great details.Especially,with the development of double-cysteine crosslinking method,force can be applied to a protein from different orientations.It was revealed that the mechanical stability of proteins is anisotropic and depends on the direction of applied forces.In parallel,it also has been revealed that ligand binding can efficiently modulate the mechanical stability of proteins.
其他文献
The major cytoskeletal protein of most cells is actin, which polymerizes to form actin filaments (F-actin).Each actin monomer (G-actin) contains a divalent
对3种朱顶红幼苗的种球直径、叶宽和叶长进行了回归分析,卡里美柔和红狮子种球直径、叶宽和叶长之间存在显著的线性关系.在新红星(杂交种)只有种球直径和叶宽存在显著的线性
Maintenance of iron homeostasis is crucial for human health.Failure to keep iron balance could lead to multiple diseases.To explore the mechanistic network
From the hindgut contents of Holotrichia parallela larvae,207 aerobic and facultatively anaerobic cellulolytic bacterial isolates were obtained.These bacter
Previous studies have shown that iron accumulation is involved in the pathogenesis of brain injury following subarachnoid hemorrhage [SAH] and blockage of m
The spatial distribution of membrane proteins is critical for receptor activation and downstream signaling.Epidermal growth factor receptor (EGFR) is a receptor
小蛋白的变性机理是人们关心的热点,对一些小蛋白的单步骤和多步骤机理一直存在争议.这里我们利用拉曼光谱研究了溶菌酶的热变性机理.我们首次对所有波段的光谱进行了完整分
通过基因组规模的遗传学筛选,我们前期鉴定出120个与Ca2+敏感相关的酿酒酵母基因。它们的功能与细胞代谢、蛋白质分选、离子稳态、转录、细胞内运输、细胞周期和高渗胁迫
分子和细胞的成像是生物医学新兴领域.成像技术中,能够探测动物和人体内细胞的磁共振成像显得尤为重.而超低场磁成像技术成为磁共振成像研究领域中最新的发展方向和挑战.我们
A combination of ab initio calculations,circular dichroism,nuclear magnetic resonance and X-ray photoelectron spectroscopy has shown that aluminum ions can indu