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The present study aims to examine the role of an endogenous gasotransmitter,hydrogen sulfide(H2S),to regulate microRNA-192(miR-192)in promoting angiogenesis.Angiogenesis was measured in vitro(endothelial cell proliferation,scratch wound healing,transwell migration and tube formation),ex vivo(aortic ring sprouting),and in vivo(Matrigel plug in mice).