【摘 要】
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Cancer stem cells (CSC) is a rare population in tumor cells that have tumor-forming,self-renewal ability and differentiation capacity [1].In recent years,in
【机 构】
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Key Laboratory of Biomass Chemical Engineering of Ministry of Education,Center for Bionanoengineerin
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
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Cancer stem cells (CSC) is a rare population in tumor cells that have tumor-forming,self-renewal ability and differentiation capacity [1].In recent years,increasing evidence has been obtained flint CSCs have crucial effects on the formation,development and metastasis,as well as multi-drug resistance of tumors.Thus,a method that could selectively eliminate CSCs is significantly important in cancer treatment.Recently,biguanidine structures like metformin,which is a commonly used diabetes drug,were discovered to have specific effects on CSCs [2].In this study,we conjugated biguanidine groups onto polymer chains to form a macromolecular biguanidine drug.The anti-CSC effect of the structure was studied in vitro in comparison with the small molecule mefformin,to verify whether it can be a good candidate for CSC inhibition.
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