Liposome is an effective carrier of chemotherapeutic drugs [1].The active targeting liposomes can delivery drug to uniquely identified sites,which can improve the efficiency,reduce the side effects of drags,while minimize harmful toxicity to non-cancerous cells adjacent to the targeted tissue [2].18bGlycyrrhetinic acid (GA) is one of the main bioactive compounds of licorice and has been widely used in medicine for the treatment of many pathologies.It was also used as a ligand for liver targeting because of the abundant receptors for GA on hepatocyte membrane.