【摘 要】
:
Colorectal cancer is the second leading cause of cancer related death in the Western World.Czech Republic is in the first place in worldwide epidemiological statistics following incidence and mortalit
【机 构】
:
Laboratory of molecular biology P&R Lab J.G.Mendel Cancer Centre Czech Republic
【出 处】
:
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Colorectal cancer is the second leading cause of cancer related death in the Western World.Czech Republic is in the first place in worldwide epidemiological statistics following incidence and mortality of this disease.Incidence onman is 95/100000, on woman is 63/100000 and mortality on man is 52/100000, on woman is 37/100000.Colorectal cancers result from the accumulation of several distinct genetic alterations that occur at the chromosomal and DNA levels.This multi-step process is characterized by inactivation of tumor supressor genes, activation of protooncogenes by mutations and/or allelic loss, or mismatch repair deficiency.In this work we analyzed 297 sporadic tumors on the molecular genetic and the immunohistochemical levels in patients from North Moravia.
其他文献
The lecture will demonstrate the collaboration and motivation of the interdisciplinary team members in making a dream come true and redefining the notion of successful palliative treatment.Our present
Ovarian cancer is the fifth most common cause of death from cancer in women.The standard first-line treatment is a combination of paclitaxel and carboplatin (DDP) or carboplatin alone.In the case of p
Discrepancy between the in-vivo and in-vitro drug sensitivity patterns of human turnout cells has been reported many times.It is often observed that drug screening tests show major differences in in-v
Ribosome-inactivating proteins such as ricin and Shiga-Like Toxin 1 (SLT-1) are highly effective at killing eukaryotic cells.Such molecules can be redirected to kill diseased cells by altering their r
The aim of the present study was to determine whether herpes simplex virus-1 (HSV-1) can be made prostate-specific and oncolytic by either co-infecting an amplicon containing a probasin-derived promot
The field of microRNA (miRNA) represents a new dimension to global regulatory networks that is important for cell development, differentiation and physiology.miRNAs are highly conserved small non-codi
Besides hypotheses that cancer stem cells (CSCs), representing a rare population of cancer cells exhibiting stem cell features such as self-renewal, differentiation, tissue regeneration and drug resis
Structural or functional inactivation of the retinoblastoma gene product (pRB) is inevitably associated with human malignancy.Mechanistically, the tumor suppressor function ofpRb is linked to its abil
Focal Adhesion Kinase (FAK) is expressed and activated at higher levels in malignant cells than in normal cells.Previously we reported that FAK knockdown in B-ALL cells causes impaired chemotactic and
Purpose: The primary aim of this study was to assess the efficacy of the Short-Term Life Review (STLR) on the spiritual well-being, as well as anxiety, depression, suffering, and happiness of terminal