The nonstructural protein 1 papain-like cysteine protease was not necessary for porcine reproductive

来源 :2013国际猪繁殖与呼吸综合征学术研讨会 | 被引量 : 0次 | 上传用户：sometimestry

【摘要】

：

【作者】

：

X.B.Shi Q.M.Li Y.Z.Chang J.Chen C.Wang P.Zhao J.F.Yang S.Z.Yang G.P.Zhang

【机构】

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Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengz

【出处】

：

2013国际猪繁殖与呼吸综合征学术研讨会

【发表日期】

：

2013年12期

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Type I IFN(IFN-alpha and IFN-beta) is the first responder against animal virus infections.When virus infects,the virus could be recognized by the pathogen-associated molecular pattern receptors and leads to the transcription of IFN-beta.Then,IFN-beta binds to the IFN-alpha/beta receptor,initiating the phosphorylation of STAT1 which induced the activation of the genes containing interferon-stimulated response element (ISRE) in their promoters and resulted in transcriptional up-regulation of these genes and establishment of an antiviral state.

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The nonstructural protein 1 papain-like cysteine protease was not necessary for porcine reproductive

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