【摘 要】
：
从胚胎发育中探索和挖掘隐藏在肿瘤细胞内的恶性信息,为肿瘤基础及临床研究提供新的线索,正逐步成为一个新的研究方向.本研究从三个方面观察了肺发育分子事件在原发性肺
【机 构】
：
分子肿瘤学国家重点实验室中国医学科学院肿瘤医院肿瘤研究所北京海淀妇幼保键医院
论文部分内容阅读
从胚胎发育中探索和挖掘隐藏在肿瘤细胞内的恶性信息,为肿瘤基础及临床研究提供新的线索,正逐步成为一个新的研究方向.本研究从三个方面观察了肺发育分子事件在原发性肺腺癌发生与发展中的作用和地位：1)人肺发育的mRNA表达特征；2)人肺发育与原发性肺癌基因表达谱相似性比较；3)人肺发育相关基因对原发性肺癌发生与发展的影响.研究结果显示,1.肺发育mRNA表达具有时间和空间特征,与组织学层面的时空变化一致；2.在肺器官发育早期高表达基因群具有干细胞性特征,与细胞增殖与分化相关；3.在成熟肺组织中高表达基因群与维持组织稳态有关,参与免疫应答、凋亡、细胞死亡等过程；4.原发性肺腺癌借用了肺发育的部分分子机理,下调稳态相关基因群和上调干细胞性相关基因群的表达.5.具有干细胞性的基因群可促进与肿瘤的发生与发展,并且影响肿瘤患者的生存预后.结论：研究结果提示：人肺发育与原发性肺腺癌的发生与发展在分子水平存在一定的共性；部分肿瘤可能是重新程序化的结果.系统整合分析器官发育与肿瘤的内在联系,是一条探索肿瘤发生与发展机理的新途径.
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