Prognostic significance ofXRCC1 gene polymorphism in diffuse-type gastric cancer in the Chinese popu

来源 :2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议 | 被引量 : 0次 | 上传用户：psoftw

【摘要】

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【作者】

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Yangmei Zhang Meilin Wang Dongying Gu Dongmei Wu Xiaomin Wu Weida Gong Yongfei Tan Jianwei Zhou Xiaojing Zhang Cuiju Tang Zhengdong Zhang Jinfei Chen

【机构】

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Department of Oncology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,PR China

【出处】

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2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议

【发表日期】

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2014年3期

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We genotyped 1022 surgically resected gastric cancer patients to investigate the prognostic effect of XRCC1 Arg194Trp polymorphism (rs1799782) on gastric cancer in the Chinese population.We found that individuals carrying at least one Trp allele had an increased risk of death compared with those with Arg/Arg homozygote (adjusted hazard ratio =1.34, 95％CI =1.05-1.71) in diffuse-type gastric cancer.Furthermore, this association was more pronounced in patients with T3 or T4 category, positive lymph node metastasis, negative distant metastasis, and stage Ⅲ or V.In conclusion, our results suggest that XRCC1 Arg194Trp could be an independent predictive marker of survival estimation and individualized medicine for gastric cancer.

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Prognostic significance ofXRCC1 gene polymorphism in diffuse-type gastric cancer in the Chinese popu

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