【摘 要】
:
The field of translational medicine and translational pharmacology centers around the desire to understand the linkage between molecular modulation and pharmacologic effect.In vitro studies provide a
【机 构】
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Integrated Sourcing Lead of External Research Solutions Pfizer Research and Development USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
The field of translational medicine and translational pharmacology centers around the desire to understand the linkage between molecular modulation and pharmacologic effect.In vitro studies provide a fertile ground for initial studies of these pathways but the ultimate goal is to define the relationship between dosage,exposure and therapeutic effect.There is a recent and growing trend in the pharmaceutical and biotech sciences to understand the PK/PD relationship for our therapeutic agents and drive structure-activity relationships from data generated in in vivo disease models.As the interest in this science expands so too does the available expertise in the external market place.Many companies and academic groups seek this service to augment their internal capacity,leverage expertise that does not reside Within their institution,or access unique disease models such as patient-specific derived xenograph models.Groups that offer "bundled" or fully integrated services supporting compound synthesis,pharmacology,formulation,in vivo disease model experience,and bioanalytic expertise are becoming key partners in this growing area.
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