Objective: Heat shock protein 90(Hsp90)is a therapeutic target for cancer treatment,and inhibition of Hsp90 will presumably result in suppression of multiple survival signaling pathways.Platycodin D(P
Objective: 2-Methoxy-6-acetyl-7-methyljuglone(MAM)is an active naphthoquinone component of Polygonum cuspidatum used as Chinese herb medicine for treatment of inflammation,hyperlipidemia and cancer.Th
Objective: Doxorubicin is a widely used antineoplastic agent in clinics for treating a wide range of cancers.However,the clinical use is largely limited by its cardiotoxicity of the heart.DS-36 is a n
Hepatocellular carcinoma(HCC)is the sixth most frequent malignant tumor with poor prognosis,and its clinical therapeutic outcome is poor.Volasertib,a potent small molecular inhibitor of polo-like kina
Regorafenib significantly prolongs overall survival in patients with metastatic colorectal cancer(mCRC),but the overall clinical efficacy of regorafenib remains quite limited.Combination chemotherapy
Multidrug resistance(MDR)is the major obstacle of the success in cancer chemotherapy.The overexpression of ATP-binding cassette(ABC)transporters,particularly ABCB1,ABCC1 and ABCG2,play a significant r
Backgrounds and Purpose: Rapamycin,an mTORC1 allosteric inhibitor with broad antitumor effects,could induce the activation of numerous negative feedback loops such as PI3K/Akt/mTOR signaling pathway,w
目的：食管癌(Esophageal carcinoma,EC)是消化道发病率最高的恶性肿瘤,易扩散转移,我国的食管癌发病率在肿瘤中高居第四。肿瘤多药耐药严重影响化疗效果,甚至导致化疗失败。因此,阐明食管癌转移及化疗耐受的分子机制,筛选鉴定相关标志物,对其进行靶向干预逆转,对提高食管癌治疗效果具有重要的理论价值和应用前景。