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Aim: To examine the effects of rutaecarpine (Rut) on myocardial hypertrophy rats,focusing on myocardial Na+-K+ ATPase (ATPase), Ca2+-ATPase and calmodulin nerve phosphatase (CaN).Methods: Left ventricular hypertrophy was induced by abdominal aortic constriction (AAC) in rats, followed by Rut treatment (20-40mg/kg, po) for 4 weeks.