DRAM1通过改善自噬流抗心肌缺血损伤的机制研究

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户：CHENGXB

【摘要】

：

目的:研究DRAM1在心肌缺血损伤中的作用及机制.方法:行大鼠左前降支冠状动脉永久性结扎术建立大鼠急性心肌梗死模型后,在结扎处附近梗死周边区注射过表达DRAM1腺病毒或阴性对照腺病毒.通过免疫印迹和免疫荧光实验检测DRAM1的表达变化.21天后,超声心动图检测大鼠左心室功能;HE染色和Masson染色观察心肌重构情况;Tunel检测心肌细胞凋亡;毛细血管密度测定观察血管新生;透射电镜观察自噬体和自

【作者】

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覃宇燕陈法江郑德冲吴晓倩

【机构】

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广州医科大学药学院药理教研室广州医科大学研究生院

【出处】

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2016第十一届心血管药理专业委员会全国心脑血管药理学术会议

【发表日期】

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2016年11期

【关键词】

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DRAM1 腺病毒急性心肌梗死心肌缺血自噬

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DRAM1通过改善自噬流抗心肌缺血损伤的机制研究

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