The GSK3-β sensing metabolism controls NLRP3 inflammasome activation

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户:cninfor
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Introduction: Glycogen synthase kinase-3 (GSK3) is composed of two isoforms, GSK3-α and-β, which reveals a new component to function differently in glucose homeostasis and promoting inflammation in multiple several prevalent diseases.Aim: To identify the role of GSK3 isoform inhibition on inflammasome activation.Methods: The NLRP3 inflammasome was activated by typical LPS/ATP and host-derived metabolites in primary mouse macrophages.
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