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目的 探讨鞘内输注雷帕霉素对骨癌痛大鼠痛觉过敏和脊髓背角p-mTOR、p-PI3K表达的影响。方法 SPF级136 Wistar大鼠40只,体重200～250 g,Walker 256乳腺癌细胞注入大鼠胫骨骨髓腔造癌痛模型。
雷帕霉素鞘内给药对骨癌痛大鼠疼痛及脊髓背角p-mTOR和p-PI3K表达的影响
【摘 要】
：
目的 探讨鞘内输注雷帕霉素对骨癌痛大鼠痛觉过敏和脊髓背角p-mTOR、p-PI3K表达的影响。方法 SPF级136 Wistar大鼠40只,体重200～250 g,Walker 256乳腺癌细胞注入大鼠胫骨骨髓腔造癌痛模型。
【机 构】
：
浙江省绍兴市人民医院(浙江大学绍兴医院)麻醉科 浙江省绍兴市人民医院(浙江大学绍兴医院)肾脏内科
【出 处】
：
中国医师协会麻醉学医师分会2016年年会
【发表日期】
：
2016年5期
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