Objective Epidermolysis bullosa(EB)is a very rare inherited disease featured with skin blistering resulting from minor trauma.Sometimes the esophageal mucosa could also be involved,which leads to esophageal strictures.The purpose of this study was to report two cases of EB related esophageal strictures and to investigate the efficacy of esophageal balloon dilation.Method The first case was a 52-year-old man who presented to our hospital complaining of a 30 years long history of dysphagia,with the symptom worsening for 5 years.He started experiencing dysphagia after swallowing a piece of hot fish when he was 22 years old.He could not take any food after admission and thus the dysphagia score was 4.Clinical examination showed blisters on the skin,loss of fingernails and toenails and deformity of hand joints.An esophagography was performed before balloon dilation and revealed two strictures at the upper esophagus.He underwent careful fluoroscopic balloon dilation with a 10mm sized balloon catheter,which was fully dilated during the procedure.The second case was a 27-year-old man who presented with progressive dysphagia for 3 years.On admission,he could only take liquid foods(dysphagia score = 3)and had the signs of malnutrition,skin blisters and loss of toenails.A tight cervical esophageal stricture was noted on the esophagography.Fluoroscopic balloon dilation was performed in this patient using a 16mm sized balloon catheter.Results Balloon dilations were successfully performed in the two patients without major complications.The dysphagia score in the first patient was improved from 4 to 1 after the procedure and maintained in the two months follow up,which means he could ingest soft and some solid foods.The dysphagia score in the second case was reduced to 2 before discharge and to 1 in the three months follow up.Conclusions As a rare skin disease,EB could affect the esophagus and cause dysphagia.Fluoroscopic balloon dilation is an effective way to improve esophageal strictures.