【摘 要】
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For the stem cell activation, it has been demonstrated that biological signaling plays a critical role in regulating stem cell fate, such as the soluble stem cell niche signals (growth factors and cyt
【机 构】
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Department of Urology, School of Medicine, University of California,San Francisco, CA 94143, USA
【出 处】
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GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
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For the stem cell activation, it has been demonstrated that biological signaling plays a critical role in regulating stem cell fate, such as the soluble stem cell niche signals (growth factors and cytokines), while recent evidence confirms that regulation of stem cell fate by these soluble factors is strongly influenced by the coexisting insoluble adhesive, mechanical, and topological cues inherently contained.These insoluble biophysical cues can be sensed and transduced into intracellular biochemical and functional responses by stem cells, a process known as mechanotransduction, Importandy, these mechanotransduction processes can couple with many other potent growth-factor-mediated signaling pathways to regulate mesenchymal stem cell (MSC) fate.Scientists have attempted to drive stem cell fate through the use of chemistry (traditional biological signaling) for decades.The results obtained on stem cell dynamics with Low energy shock wave add further evidence on the feasibility of using a physical energy to drive stem cell growth and fate, and may pave new way to regenerative treatments performed without the need of stem cell transplantation.
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