【摘 要】
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The Chinese Society of Biochemistry and Molecular Biology Tumor radiotherapy can cause hematopoietic organ damage,the clinical manifestations of a variety of blood cell count decreased.For example the
【机 构】
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Fudan university Shang hai 200030
【出 处】
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中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
The Chinese Society of Biochemistry and Molecular Biology Tumor radiotherapy can cause hematopoietic organ damage,the clinical manifestations of a variety of blood cell count decreased.For example the number of leukocyte and platelets decreased.The decrease in the number of leukocyte will cause the immune function of the body to reduce,causing a variety of infections and so on.The decrease of the number of platelets in the blood can lead to the decrease of the blood coagulation function,the fragility and permeability of the blood vessel wall,and even lead to more serious clinical symptoms.Leukopoietin can effectively improve the number of leukocyte in the clinic.But there is still lack of safety and effectiveness drugs on platelet enhancing.Some research shows that tRNA synthetase has not only catalytic tRNA aminoacylation role,but also has the function of cytokines.For example tyrosyl tRNA synthetase(Y341A)internal folding formation of a hydrogen bond network hydrophobic structure destruction of the original in internal ELR motif is exposed outside,also changed the N terminal fragment and its C terminal fragment,which are able to exercise the function of cytokines.The mutant tRNA synthetase showed the function of promoting platelet production,but the specific mechanism is unknown.The purpose of this paper is to through animal experiments to explore the therapeutic effect of rhTyrRS(Y341A)in the treatment of thrombocytopenia and its mechanism.Respectively effect of rat verified rhTyrRS(Y341A)on platelet number and validate the effects of mice to test rhTyrRS(Y341A)on platelet number after radiotherapy and using zebra-fish as rhTyrRS(Y341A)model organism for the study of the promotion of platelet mechanism.It is expected that it become a more safe and effective drug to enhance platelet through the study of RhTyrRS(Y341A).
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