Study on preparation and intestine absorption of collagen peptide loaded sodium alginate-chitosan mi

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户:mm74481
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Although collagen peptide has been used in therapeutic applications for a long time, the absorption mechanism is not well understood.
其他文献
[目的]三氯生是一种羟二乙醚的三氯化衍生物,被广泛应用于日用化学品、化妆品、洗涤剂、医疗消毒及卫生保健产品中,是使用范围较为广泛的一类抗菌剂,可通过各种途径与人体接触,并易被皮肤吸收。有研究报道三氯生的急性经口和经皮毒性较低,但三氯生的使用特点决定了其与皮肤及粘膜接触的机会较多,因此我们开展亚慢性经皮毒性试验进行三氯生长期经皮接触吸收后的毒理学安全性评价。目的:开展三氯生亚慢性经皮毒性试验,为其安
[目的]长期慢性铅暴露损害发育期脑神经系统.通过动物模型构建探究丹参酮ⅡA对铅中毒大鼠脑损伤的保护作用及其产生作用的机制.[方法](1)SD大鼠模型构建,分组:①空白对照组:饮用去离子水;②铅中毒组:饮用0.2%的醋酸铅水溶液;③2.5mg/kg丹参酮ⅡA+铅中毒组:在铅中毒模型构建时同时给予2.5mg/kg的丹参酮ⅡA;④2.5mg/kg丹参酮ⅡA+空白对照组.以上动物分组均为出生21天大鼠,且
[目的]选取上海船厂崇明造船基地作为造船环节防污漆的典型暴露场景,以敌草隆为防污漆活性物质,分别采用MAMEPC以及EUSES软件对造船过程中释放的防污漆活性物质的进行暴露评估比较分析.[方法]以2012年上海船厂建造完工的主要民用船舶为统计对象,根据不同尺寸的船长计算涂覆防污漆的表面积.计算上海船厂全年防污漆的使用量.为了更准确地对上海船厂周围区域环境进行风险评估,相关的水文水质参数和化合物性质
[目的]既往研究表明塑化剂DEHP可诱导人类和啮齿动物出现肥胖和甲状腺功能减退,但其内在分子机制不明.本研究的主要目的是探明DEHP诱导肥胖症和甲状腺功能减退的内在分子机制,并尝试探索两种健康风险之间的内在关联.[材料和方法]我们用0.5、5、50、200mg/kg BW/day的DEHP对雄性C3H/He小鼠进行了为期5周的灌胃染毒,在此期间对小鼠的体重、摄食量和体温进行了定时监测.并在5周的暴
Nanotechnology-based drug delivery systems are used for the efficient delivery of therapeutic agents,especially nanocrystals (NCs) were utilized as oral formulations in several commercial products to
会议
PURPOSE: As a versatile drug carrier with three dimension nanostructure of inherent inner bicontinuous water channels and curved lipid bilayer, cubosome exerts excellent delivery capacity for both hyd
会议
Systemically administered anticancer treatments were greatly limited by extensive side effects mainly due to nonspecific distributions in vivo and multidrug resistance in various tumors.A phospholipid
会议
Nanobubbles represent a promising nano-sized ultrasonic contrast agent for tumor targeting ultrasonic imaging.Novel amphiphilic PAEEP-PLLA copolymer was synthesized by ring-opening polymerization reac
会议
Based on the excellent characteristics of chitosan (CS) and methoxy poly(ethylene glycol) (mPEG), a series of methoxy poly(ethylene glycol)-grafted-chitosan (mPEG-g-CS) were synthesized and utilized i
Retinal diseases are the primary causes for visual impairment.One of the greatest challenges for retinal diseases therapy is low efficiency of topical administration.The purpose of this study is to pr