【摘 要】
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Glyconanomaterials, nanomaterials carrying immobilized glycans, combine the unique properties of nanometer-scale objects with their ability to present multiple
【机 构】
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LifeTechnologiesInc.,Eugene,ORDepartmentofChemistry,UniversityofMassachusettsLowell,MA
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Glyconanomaterials, nanomaterials carrying immobilized glycans, combine the unique properties of nanometer-scale objects with their ability to present multiple copies of glycan ligands.1 These new materials have demonstrated potentials in biomedical imaging, therapeutics, and diagnostics.We develop a new method to synthesize glyconanomaterials,which applies to a variety of carbohydrate structures and does not require chemical derivatization of the glycan ligands.2 Subsequently, four analytical methods, based on fluorescence competition assay,3 dynamic light scattering,4 isothermal calorimetry,5 and super-microarray6 have been developed to determine the binding affinity (Kd) of glyconanomaterials with lectins.Results showed that the affinity of glyconanomaterials with lectins were several orders of magnitude higher than those of free ligands with lectins.
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