IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt p

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Our previous studies indicated that Brn-4 is upregulated in the surgically denervated hippocampus in vivo and promotes neuronal differentiation of hippocampal neural stem cells (NSCs) in vitro.The molecules mediating Brn-4 upregulation in the denervated hippocampus remain unknown.
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