Type Ⅰ Interferon-inducible Phosphorylation of Ser82 on IRF3 Acts as a Negative-feedback Regulation

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：WZX10

【摘要】

：

【作者】

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Shun Li Mingzhu Zhu Ting Fang Deyin Guo

【机构】

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State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuha

【出处】

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中国细胞生物学学会2015年全国学术大会

【发表日期】

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2015年4期

【关键词】

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IRF3 IFN-α/β negative phosphorylation

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　　Interferon regulatory factor 3 (IRF3) plays an essential role in virus-induced type Ⅰ interferon (IFN) production and host antiviral immune responses.However, excessive immune responses will do harm to host and lead to autoimmune diseases.Thus, IRF3 must be finely tuned to give proper responses to virus infection.

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Type Ⅰ Interferon-inducible Phosphorylation of Ser82 on IRF3 Acts as a Negative-feedback Regulation

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