【摘 要】
：
BNIP3 is regulated by hypoxia through hypoxia-inducible factor 1(HIF-1), which binds to hypoxia response element (HRE) in the promoter of BNIP3 and activate
【机 构】
：
Beijing Institute of Basic Medical Sciences
【出 处】
：
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
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BNIP3 is regulated by hypoxia through hypoxia-inducible factor 1(HIF-1), which binds to hypoxia response element (HRE) in the promoter of BNIP3 and activates its transcription.It is unknown how different degrees of hypoxia regulate BNIP3 and what role BNIP3 plays in determining cell fate with respect to regulation of mitophagy and apoptosis.In this study, we found that mitophagy was the dominant activity under moderate hypoxia (10% O2) and that apoptosis was the dominant activity under severe hypoxia (0.3% O2).The different activities were related to the differential regulation of BNIP3 by varying degrees of hypoxia.Moderate hypoxia increased the BNIP3 protein level, which promoted mitophagy and cell survival.Severe hypoxia decreased the BNIP3 protein level, which resulted in apoptosis and cell death.Thus,we propose that the BNIP3 protein level plays a pivotal role in determining the choice of mitophagy or apoptosis pathways.Unlike previous reports, we are the first to discover that BNIP3 down-regulation rather than up-regulation leads to apoptosis and cell death.
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