Launch of Genexol-PM,A Novel Polymeric Micelle Formulation of Paclitaxel Using a Novel DDS Technolog

来源 :BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中 | 被引量 : 0次 | 上传用户:ntieing
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  In March of 2007 Samyang Corporation has launched a novel taxane formulation, "Genexol-PM", in Korean market after 9 years of development.Genexol-PM has a polymeric micelle system to load paclitaxel and is free from Cremophor (CrEL) which causes various toxic effects.Genexol-PM polymeric micelles are composed of hundreds of amphiphilic diblock copolymers.Block copolymers including poly-(ethylene glycol) and poly-(D,L-lactic acid) are required for solubilization of hydrophobic drug.The micelle particle sizes are in a diameter of 20-50 nm.
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