CCI大鼠脊髓背角血管内皮生长因子与ERK信号通路的相关性研究

来源 :中华医学会疼痛学分会第十一届学术年会 | 被引量 : 0次 | 上传用户：greatkinghg

【摘要】

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【作者】

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肖丹程智刚孔高茵潘冰冰丁惠娟王云姣郭曲练

【机构】

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湖南省人民医院麻醉科中南大学湘雅医院麻醉科,长沙市410005

【出处】

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中华医学会疼痛学分会第十一届学术年会

【发表日期】

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2014年7期

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目的:探讨脊髓背角血管内皮生长因子(VEGF)在大鼠神经病理性痛中的作用及其与胞外信号调节激酶(ERK)信号通路的关系.方法:20只雄性SD大鼠,2月龄,体重160～320g,采用随机数字表法,将其分为4组(n=5):假手术组(S组)、神经病理性痛组(CCI组)、生理盐水组(NS组)和VEGF抗体组.S组仅暴露左侧坐骨神经但不进行结扎,其余各组采用坐骨神经慢性压迫性损伤(CCI)制备神经病理性痛模型.VEGF抗体组于CCI术后2h开始鞘内注射VEGF抗体0.3 μg/15 μl,以后每2d注射1次,共4次;NS组给予等容量生理盐水.于CCI术前1 d(T1)、CCI术后1、3、5、7d (T2-5)时测定机械痛阈(PWMT)和热痛阈(PWTL).

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CCI大鼠脊髓背角血管内皮生长因子与ERK信号通路的相关性研究

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