Synthesis of Naphthalimide-derived Fluconazole as Antimicrobial Agents

来源 :中国化学会第十六届全国有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：kevin_0713

【摘要】

：

【作者】

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Yan-Fei Sui Lavanya Gopala Cheng-He Zhou

【机构】

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College of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715

【出处】

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中国化学会第十六届全国有机合成化学学术研讨会

【发表日期】

：

2019年3期

【关键词】

：

naphthalimide fluconazole antibacterial antifungal

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　　A series of new potentially multi-targeting antimicrobial naphthalimide-derived fluconazole analogs were designed and conveniently synthesized from 4-bromonaphthalic anhydride.Their structures were characterized by 1H NMR,13C NMR and HRMS spectra.Bioactivity assays revealed that some prepared compounds exhibited significantly inhibitory efficiencies towards bacteria and fungi.Remarkably,the derivative 11e could effectively inhibit the growth of Acinetobacter baumannii with MIC value of 0.013 μmol/L.

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Synthesis of Naphthalimide-derived Fluconazole as Antimicrobial Agents

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