【摘 要】
：
Non-targeted metabolomics experiments performed in the Cornell EnHANCE cohort of young adults followed over the course of their first year of college identi
【机 构】
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DivisionofNutritionalSciences,CornellUniversity,Ithaca,NY,USA
【出 处】
：
2017精准健康和精准营养国际研讨会
论文部分内容阅读
Non-targeted metabolomics experiments performed in the Cornell EnHANCE cohort of young adults followed over the course of their first year of college identified erythritol as a novel biomarker of central adiposity gain.Erythritol levels in pooled plasma from individuals exhibiting central adiposity gain were nearly 15-fold higher than in plasma from individuals with stable adiposity and nearly 23-fold higher in individuals with higher glycemia compared to those with lower glycemia.Erythritol is a four-carbon sugar and low-calorie sweetener/food additive that is rapidly absorbed then excreted in urine following ingestion.Stable isotope tracer experiments demonstrated that erythritol is formed from reduction of erythrose,which is produced from erythrose-4-phosphate,a pentose phosphate pathway intermediate.Others have shown that serum erythritol is increased in diabetic patients with retinopathy.
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