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Type 2 diabetes mellitus(T2D)is a metabolic disease characterized by hyperglycemia with complex etiology.There are about 100 million adults with diabetes in China.Long term hyperglycemia may cause multiple organ injuries including stroke,blindness,myocardial infarction,renal failure and amputation.So far,the research and development of early warning and individualized treatment of diabetes is still a worldwide problem.Genetic markers can provide early warning information before obesity,abnormal glucose regulation and other clinical phenotypes appear.Therefore,we aim to analyze the genetic etiology of T2D and investigate early genetic markers for the occurrence and development of T2D in Chinese population for the guidance of clinical prevention and individualized treatment.