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We consider how to identify Q-Matrix of Markov Chain for Model of Ion Channel.Markov inversion approach is developed to perform a difficult inversion to identify Q-Matrix from the parameters characterizing the lifetime distributions at a small number of states,although it is straightforward to derive the lifetime distribution.The general explicit equations relating the parameters of the lifetime distribution to Q-Matrix are derived and Q-Matrix are then obtained as roots to this system of equations.The concrete solutions are proposed to the basic and regular schemes such as linear,star-graph branch and loop.Useful conclusions and solutions to realistic schemes are also included to show its efficiency.