Impaired diabetic wound healing is one of major complications of diabetes mellitus,and can have a long-term negative effect on the quality of life,morbidity and mortality.Moreover,chronic,nonhealing diabetic ulcers may produce a high risk of re-hospitalization and strained healthcare budgets.According to some pathological views of diabetes,disturbances in collagen metabolism,delayed reepithelialization in wounds,and impaired migration and proliferation of keratinocytes and fibroblasts are the main causes of delayed wound healing [1].The development of treatment methods to improve the healing of diabetic wounds is therefore urgently sought.In the present authors earlier study,glucophage-eluting poly-D-L-lactide-glycolide (PLGA) nanofibrons membranes enhanced reepithelialization in the treatment of diabetic wounds [2].Nonetheless,the mechanism of repairing action of glucophage remains imperfectly understood.