HLAⅠ类抗原呈递通路基因ERAP1和ERAP2基因多态性与丙型肝炎病毒慢性感染的相关性研究

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：fjyasp

【摘要】

：

背景:在机体病毒感染后的清除中,宿主免疫应答发挥了重要的作用.与抗原递呈密切相关的HLA系统,在对病毒的有效应答中起着关键作用.内质网氨肽酶1和2 (endoplasmic reticulum aminopeptidase 1 and 2,ERAP1 and ERAP2)是抗原递呈中的重要分子,已有研究报道,ERAP1基因的多态性与自身免疫性疾病、慢性感染性疾病的发生发展有着密切的关联性.目的ER

【作者】

：

沈云松姚月婷曹丹凤李莹马雁冰史荔姚宇峰

【机构】

：

云南省第一人民医院中国医学科学院&北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

ERAP基因 HCV 慢性感染单核苷酸多态性

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HLAⅠ类抗原呈递通路基因ERAP1和ERAP2基因多态性与丙型肝炎病毒慢性感染的相关性研究

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