【摘 要】
：
Though researchers found 300 new RNA binding proteins in human cell, and a lot of binding sites of RBPs(RNA-binding proteins) in 3-UTR in mRNAs.However, it is still unknow for most RBPs to get their t
【机 构】
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Department of Physics, Huazhong University of Science and Technology, Hubei, 430074
【出 处】
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第七届国际分子模拟与信息技术应用学术会议
论文部分内容阅读
Though researchers found 300 new RNA binding proteins in human cell, and a lot of binding sites of RBPs(RNA-binding proteins) in 3-UTR in mRNAs.However, it is still unknow for most RBPs to get their targeting sites in transcriptome.So, it is necessary to develop a method that could predict RNA-protein interaction.If 3D structures of protein and RNA are available, could we predict the 3D RNA-protein complex structure? For RNA-protein complex structure prediction, we have developed a RNA-protein docking method RPDock, which achieved more than 30% for top 10 prediction, and was 9% better than the best method reported in literature(Sci Rep, 2013,1887).At the same time, we also compiled a binding affinity dataset(Protein Sci, 2013,1808-1811) for RNA-protein interaction, which may help for developing effective scoring function of RNA-protein interactions.
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