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  5. Sphingosine kinase 2-mediated autophagy contributes to preconditioning by isoflurane in mouse cortic

Sphingosine kinase 2-mediated autophagy contributes to preconditioning by isoflurane in mouse cortic

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：pridekao
【摘 要】
：
Aim: Sphingosine kinase 2 (SPK2) and autophagy are both involved in cerebral preconditioning, but whether preconditioning-induced SPK2 upregulation and autophagy activation are linked mechanistically
【作 者】
：
Rui SHENG Tao QIN Zheng-hong QIN Charles D SMITH Ellen SAPP Marian DIFIGLiA Christian WAEBER 
【机 构】
：
Stroke and Neurovascular Regulation Laboratory,Department of Radiology, Massachusetts General Hospit
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
sphingosine kinase 2 isoflurane preconditioning autophagy cortical neurons coimm 
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Aim: Sphingosine kinase 2 (SPK2) and autophagy are both involved in cerebral preconditioning, but whether preconditioning-induced SPK2 upregulation and autophagy activation are linked mechanistically remains to be elucidated.In this study, we used in vitro and in vivo models to explore the role of SPK2-mediated autophagy in isoflurane (ISO) and hypoxic preconditioning (HP).
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