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Repopulation of surviving tumor cells is an important cause of treatment failure.Cancer stem cells (CSCs) are the root of cancer and responsible for caner relapse and drug resistance.They could survive chemotherapy and sustain tumor regrowth.Here in consideration of excellent drug resistant overcoming capacity, the chitosan-g-stearic acid (CSOSA) polymeric micelles were used as the drug delivery system (DDS) to remove CSCs.