Maintenance of desired cell phenotype is always essential toward functional tissue regeneration,which is at least equally if not more important when it comes to in vitro creation of implantable tissue constructs.Increasing evidence has demonstrated that in tissue engineering the scaffolds not only provide the cells with a temporary support for attachment and growth,but also instruct the cells for their fate.In contrast to a tremendous knowledge base on the effect of biochemical factors,limited understanding has been made in correlating the physical characteristics of scaffolds with cellular responses.