Huntingtons disease(HD)is an inherited genetic disorder that leads to degeneration of brain cells primarily in Striatum and Cortex and consequently results in abnormal body movements,decreased mental
Alzheimers disease is the most common cause of neurodegeneration in the elderly.Since cholinergic deficit and excitatory amino acid toxicity are the well recognized pathologies in the Alzheimers brain
In recent years,our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain.We found that cancer cells produced formaldehyde through demethylation
Bone cancer-induced pain is one of the most severe types of chronic pain.Approximately 90% of advanced bone cancer patients must cope with chronic pain syndromes related to tumor progression and faile