The PCNA-dependent E3 ubiquitin ligase Cul4-Ddb1-Cdt2 mediates S-phase degradation of the nuclease r

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户:wish_hjl
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Structure-specific nucleases play crucial roles in DNA replication and DNA repair.The mechanisms of their regulation are not fully understood.Recently we reported a fission yeast protein, Pxd1, that regulates DNA repair by activating the Rad16-Swi10 nuclease and inhibiting the Dna2-Cdc24 nuclease.
其他文献
DNA double strand breaks (DSBs) that are repaired by homologous recombination (HR) are first resected 5-3by the combined action of the Mre11-Rad50-Nbs1 (MRN),Ctp1, Exo1 and Rqh1-Top3-Dna2 into the ssD
会议
Focusing on the roles of progressive telomere deprotection in cells approaching replicative senescence, we discovered that critically short telomeres signal differently than intrachromosomal DNA break
会议
DSBs induced in heterochromatic regions are repaired with slow kinetics by a process requiring ATM, Artemis and ATM signaling factors.This process represents homologous recombination in G2, but its na
会议
The expression level of SLFN11 is causally associated with the activity of DNA-damaging agents in human cancer cells.However, little is known about the mechanism by which this occurs.Here we show that
会议
Ataxia Telangiectasia (AT) is a rare monogenic disorder, inherited as autosomal recessive, characterized by progressive cerebellar ataxia associated with loss of Purkinje cells, oculocutaneous telangi
会议
Ataxia-Telangiectasia (A-T) is the most prominent among the inherited neuropathological disorders caused by defects in the DNA damage response pathway.Albeit neurodegeneration in A-T has initially bee
会议
Introduction: Ataxia Telangiectasia (A-T) is a rare genetic disorder with symptoms including ataxia and involuntary movements, higher risk of infections, and high risk of cancer [1].There is currently
会议
The loss of Ataxia Telangiectasia Mutated (ATM) protein function is a frequent event in the pathogenesis of sporadic haematopoietic malignancies such as Chronic Lymphocytic Leukaemia (CLL), T-Prolymph
会议
Fanconi anemia (FA) is a rare genetic disease characterized by genome instability,cancer predisposition, bone marrow failure and various developmental abnormalities.Here we report two unrelated Japane
会议
Nijmegen breakage syndrome (NBS) as well as Ataxia Telangiectasia (A-T) is a radiation-hypersensitive genetic disorder, showing chromosomal instability, radioresistant DNA synthesis, and predispositio
会议