磷酸酶PTP-PEST通过选择性抑制IKKβ/NF-κB信号通路活化负向调控Toll样受体触发的天然免疫反应

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：jhzdw1982

【摘要】

：

研究背景:Toll样受体(Toll-like receptor,TLR)作为重要的模式识别受体,能选择性识别病原相关分子模式,启动天然免疫应答.TLR信号过度活化或活化不足会导致机体免疫功能异常,因而TLR活化受到严密调控.既往有报道数个酪氨酸磷酸酶以不同机制调控TLR信号转导.酪氨酸磷酸酶PTP-PEST在造血细胞中广泛表达,同时与T细胞、B细胞等免疫细胞的活化调控密切相关,但其在天然免疫中所起

【作者】

：

张鹏刘星光李盈科孟君李楠曹雪涛

【机构】

：

第二军医大学免疫学研究所暨医学免疫学国家重点实验室

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

Toll样受体磷酸酶 PTP-PEST NF-κB

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