Maturation, Migration, and Homeostasis of Murine CD4+ Pre-Thymic Emigrants

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  After a tightly regulated developmental program in the thymus, "mature" single positive (SP) thymocytes leave the thymus and enter the periphery.These newly arrived recent thymic emigrants (RTEs) are phenotypically and functionally immature, and will complete a dynamic maturation in the peripheral lymphoid organs before being licensed to be resident naive T cells.
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